General Information

  • ID:  hor001343
  • Uniprot ID:  E9HK97
  • Protein name:  FIRFamide2
  • Gene name:  NA
  • Organism:  Daphnia pulex (Water flea)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Daphnia (genus), Daphniidae (family), Anomopoda (infraorder), Cladocera (suborder), Diplostraca (order), Phyllopoda (subclass), Branchiopoda (class), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DEERSFHPARPSRSLRSNFIRF
  • Length:  22(146-167)
  • Propeptide:  MNGLRFLMLILGLMMIVGQVRPDDETSEEDVDDENFLSGSNAAAAAGSSDSAEEDDDNNNNKGGIELYLSAMKDLYRQSKRHEAEPLVSSRSGASAPIAALYRRSALNKNFIRFGRSGGGVMKTDVSRQMQPIRLMGLNESDSGKDEERSFHPARPSRSLRSNFIRFGRSFFPTSNRWGETVRRSARRTPSAGRQMMSLVDLPASSSSSSRR
  • Signal peptide:  MNGLRFLMLILGLMMIVGQVRP
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E9HK97-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001343_AF2.pdbhor001343_ESM.pdb

Physical Information

Mass: 307970 Formula: C118H182N40O34
Absent amino acids: CGKMQTVWY Common amino acids: R
pI: 11.9 Basic residues: 6
Polar residues: 5 Hydrophobic residues: 6
Hydrophobicity: -125.45 Boman Index: -10125
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 40
Instability Index: 11991.36 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21830762
  • Title:  Genomics, Transcriptomics, and Peptidomics of Daphnia Pulex Neuropeptides and Protein Hormones